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Ray has written about several natural compounds that may be helpful for supporting optimal skin health in areas that have moles, spots, blemishes, etc. The natural compounds naringenin and apigenin are the ones most extensively researched for that purpose, but caffeine is also a very beneficial one and already used as part of the SolBan supplement. In addition to supporting skin health, caffeine also helps increase the absorption of both naringenin and apigenin, and that is another reason for its presence in MelaNon.
The topical doses used in most studies correspond to about 2mg for a human and that applies for both naringenin and apigenin.
Note: This product contains raw material(s) meant for external use only, in cosmetic or other formulations designed for such external use. The units listed on the label are just for measurement purposes. They do not indicate or suggest optimal dose.
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MelaNon is dietary supplement for skin health. It contains the citrus flavonoid naringenin as well as the flavone apigenin most commonly found in chamomile. MelaNon also contains caffeine for improved estrogen control and skin health. All of the ingredients have been extensively studies for health purposes, but most of the research on naringenin / apigenin focuses on their anti-neoplastic effects, and especially their effects on skin formations such as moles of various types. This product, while consisting entirely of food-grade ingredients, is sanctioned for external use only.
Servings per container: about 30
Serving size: 8 drops
Each serving (8 drops) contains the following ingredients:
Apigenin - 3mg
Naringenin - 3mg
Other ingredients: add product to shopping cart to see info
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References:
http://www.functionalps.com/blog/2013/1 ... aringenin/
"...Orange juice contains naringenin which is effective against melanoma, and guavas contain apigenin, also effective. A diet consisting of milk, orange juice, guavas, cheese, and some eggs, liver, and oysters, with aspirin would be protective against the spread of the tumor.”
http://raypeat.com/articles/articles/th ... trix.shtml
"...Substances that inhibit inflammation are likely to also inhibit excessive collagen synthesis, serotonin secretion, and the formation of estrogen. Besides aspirin, some effective substances are apigenin and naringenin, found in oranges and guavas. These flavonoids also inhibit the formation of nitric oxide and prostaglandins, which are important for inflammation and carcinogenesis (Liang, et al., 1999). Increased CO2, which has a variety of anti-inflammatory effects, can decrease collagen formation and tissue collagen content significantly (Ryu, et al., 2010)."
Naringenin:
Tumor growth attenuating effects of naringenin. - PubMed - NCBI
Inhibitory effect of GB-2a (I3-naringenin-II8-eriodictyol) on melanogenesis. - PubMed - NCBI
Apigenin:
Apigenin: a promising molecule for cancer prevention. - PubMed - NCBI
Topical apigenin alleviates cutaneous inflammation in murine models. - PubMed - NCBI
Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells. - PubMed - NCBI
Src kinase is a direct target of apigenin against UVB-induced skin inflammation. - PubMed - NCBI
The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes. - PubMed - NCBI
Treatment of dermatophytosis by a new antifungal agent 'apigenin'. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/26278529
http://www.ncbi.nlm.nih.gov/pubmed/26150153
http://www.ncbi.nlm.nih.gov/pubmed/24077511
http://www.ncbi.nlm.nih.gov/pubmed/8899846
http://www.ncbi.nlm.nih.gov/pubmed/8956339
Caffeine:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129466/
http://www.ncbi.nlm.nih.gov/pubmed/25591953
http://www.ncbi.nlm.nih.gov/pubmed/21505179
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353410/
http://www.ncbi.nlm.nih.gov/pubmed/18179623
http://www.ncbi.nlm.nih.gov/pubmed/17388926