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CortiNon

Store/Lab/R&D Chemicals
$39.99
Solvent | P4:DHEA Ratio
In stock
1
Maximum purchase quantity: 4 items
Product Details

This product does not really need any introduction to anybody familiar with Peat's work. I have wanted to release it for a long time but over the last few months the studies I found related to the anabolic and anticatabolic effects of progesterone, combined with the fact that Peat has told quite a few people over email that he used this combination of steroids, convinced me that it is worth it.

Unlike other products, there won't be as many references listed in support of this product but I think even the few ones below are enough to give an idea about its properties.

The name CortiNon was coined due to the known main effects of both progesterone and DHEA - i.e. antagonism to cortisol: (1) at the receptor level (progesterone); (2) enzymatically (11b-HSD1 & 11bHSD2) and functionally by both progesterone and DHEA.

The units listed on the label are just for measurement purposes. They do not indicate or suggest optimal dose. Please note that similar to the liquid products sold by companies like Sigma Aldrich, Spectrum Chemical, Alfa Aesar, etc, this product if for lab/research use only.

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CortiNon is a combination of the steroids progesterone and DHEA, which have a number of desirable properties as demonstrated by numerous studies - i.e. anti-glucocorticoid, anti-inflammatory, anti-endotoxin, anti-viral, anti-mutagenic, antimicrobial, anti-cancer, anxiolytic, antidepressant, and generally anti-aging.

Drops per container: about 360

Each drop contains the following ingredients:

Progesterone (USP): 3mg

DHEA (USP): 1mg

Other ingredients: add product to shopping cart to see info

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REFERENCES:

Anti-aging

https://raypeatforum.com/community/threads/kmud-1-...

https://raypeatforum.com/community/threads/topical...

Effects and side-effects of 2% progesterone cream on the skin of peri- and postmenopausal women: results from a double-blind, vehicle-controlled, randomized study - PubMed

The results of this study demonstrate that topical 2% progesterone acts primarily in increasing elasticity and firmness in the skin of peri- and postmenopausal women. These effects in combination with good tolerability make progesterone a possible treatment agent for slowing down the ageing...

Anti-Catabolic / Myotrophic / Androgenic

1. Progesterone

The Anti-cortisol Mechanism Of Progesterone

The Anabolic Effects Of Progesterone

Progesterone Is Androgenic

Progesterone Is As Anabolic For Muscle As Testosterone (in Women)

2. DHEA

DHEA, In Low Doses, Directly Inhibits Cortisol Synthesis

DHEA Enhances Cortisol Degradation

DHEA Has Very Similar Anabolic Activity To DHT

DHEA, a selective glucocorticoid receptor antagonist: its role in immune system regulation and metabolism. - PubMed - NCBI

Low-dose DHEA Inhibits Aromatase By 35% And Endotoxin Blocks That Effect

3. Combination

The Requirements For An Optimal Anticatabolic / Anabolic Substance (progesterone + DHEA)

Ray Peat Email Advice Depository

6-Ketoprogesterone and its biological actions. - PubMed - NCBI

"...The results are summarized in Table 6. The extracts of the samples, in which progesterone and dehydroepiandrosterone were used as substrate resulted in the strongest hypertrophy of the preputial gland and had the strongest myotrophic action of all. Both of the actions of the products which come from the incubation of the villus with 17(a)-hydroxyprogesterone were much weaker."

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