This steroid (a metabolite of progesterone) does not need much introduction, but it is essentially the most potent endogenous GABA agonist in the human body and its deficiency due to ill health, old age, or usage of drugs such as finasteride has been implicated in many physiological and mental disorder.
The units listed on the label are just for measurement purposes. They do not indicate or suggest optimal dose. Please note that similar to the liquid products sold by companies like Sigma Aldrich, Spectrum Chemical, Alfa Aesar, etc, this product if for lab/research use only.
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Allopregnanolone is a metabolite of progesterone through the action of the enzymes 5α-reductase (5-AR) and 3α-HSD. Unlike progesterone and 5α-DHP, it is NOT an agonist of the progesterone receptor (PR). However, like progesterone and 5α-DHP, it is an agonist of the GABA receptor and is perhaps the most potent endogenous GABA agonist. Due to its 5-AR derived nature allopregnanolone can serve as a precursor to androgens such as DHT, androstanedione, and androsterone through a recently discovered alternative pathway. Allopregnanolone levels drop in cases of severely downregulated 5-AR activity due to stress, PUFA overload, chronic disease, aging, and administration of 5-AR like finasteride or dutasteride (i.e. the (in)famous Post Finasteride Syndrome (PFS)).
Drops per container: about 250
Each drop contains the following ingredients:
Allopregnanolone: 1 mg
Other ingredients: add product to shopping cart to see info
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REFERENCES:
https://en.wikipedia.org/wiki/Allopregnanolone