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10-Methoxy-Harmalan

Store/Lab/R&D Chemicals
$59.99
Solvent
In stock
1
Maximum purchase quantity: 2 items
Product Details
MSDS: https://www.sigmaaldrich.com/US/en/sds/aldrich/m1626

The units listed on the label are just for measurement purposes. They do not indicate or suggest optimal dose. Please note that similar to the liquid products sold by companies like Sigma Aldrich, Spectrum Chemical, Alfa Aesar, etc, this product if for lab/research use only.

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A naturally occurring (e.g. in tobacco) β-carboline derivative, 10-methoxy-harmalan (10-MeO-Harmalan) has been shown to act as a serotonin antagonist both in-vitro and in-vivo, with a mechanism and potency similar to the ergot derivatives, but without their psychotropic/hallucinogenic effects. In addition, several studies suggest dopaminergic effects of most naturally occurring β-carbolines. The chemical is currently not known to be regulated/restricted and is available commercially from a number of major chemical vendors.

Drops per container: about 250

Each drop contains the following ingredients:

10-MeO-Harmalan: 100 mcg

Other ingredients: add product to shopping cart to see info

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REFERENCES:

https://doi.org/10.1126/science.134.3480.674

https://cellandbioscience.biomedcentral.com/articl...

"...A common feature of the immune cells of mammals and insects is the occurrence of serotonin receptors. Qi et al. [15] identified 5-HT1B, 5-HT2B, and 5-HT7 receptor expression in naive insect hemocytes, but only 5-HT1B and 5-HT2B appeared to have functional roles. While blockade of 5-HT1B significantly reduced phagocytic ability, blockade of 5-HT2B increased hemocyte phagocytosis. Harman and norharman are antagonists of both type 5-HT1 and 5-HT2 serotonin receptors,.."

https://pubmed.ncbi.nlm.nih.gov/21651332/

https://pubmed.ncbi.nlm.nih.gov/32285253/

https://onlinelibrary.wiley.com/doi/full/10.1111/j...

https://pubmed.ncbi.nlm.nih.gov/17883257/

https://www.sciencedirect.com/science/article/abs/...

https://pubmed.ncbi.nlm.nih.gov/15610033/

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